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Proteins at their best: crystals!

Getting bored on a Sunday night, I have decided to get lost into the world of protein crystals. Insulin is used as a crystal and they are even studied as functional materials nowadays.

To read more about them click HERE.

NEW FLOWERS@SHOP

I like playing with colors to drive attention to the beauty of nature.

I hope you like the effect on this tiny backpack ūüôā

a stringy backpack with flowers  by poetry from the lab

5IP3: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the Tomato spotted wilt tospovirus nucleocapsid protein-ssDNA complex¬†… one of the natural enemies of tomatoes but in purple!

Tomato spotted wilt tospovirus nucleocapsid protein-ssDNA complex

Tomato spotted wilt virus is a spherical negative-sense RNA virus that has a diameter around 100 nm.  It is one of the most economically devastating plant viruses in the world. Transmission can only occur when larvae stage thrips acquire the virus. The larvae stage for thrips lasts around 1-3 days. The virus is acquired by thrips when they feed on infected plants.  (read more DOI: 10.1128/JVI.01002-17 and Wikipedia)

4cpa: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the POTATO CARBOXYPEPTIDASE … one of the nemesis of proteins, argh!!

REFINED CRYSTAL STRUCTURE OF THE POTATO INHIBITOR COMPLEX OF CARBOXYPEPTIDASE A AT 2.5 ANGSTROMS RESOLUTION

A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.(read more DOI: 10.1038/nature06956 and Wikipedia)

3cl0: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the Neuraminidase such a surprising vegetable.

N1 Neuraminidase H274Y + oseltamivir

Neuraminidase is a key protein of influenza viruses and in this structure one inhibitor is also present bound to it. The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. The study of neuraminidases and how they evolve, and the research of novel inhibitors are key for having antiviral drugs in the future (read more DOI: 10.1038/nature06956 and Wikipedia)

4q9c: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the IgNAR antibody domain C3… a protein from shark! what else can I say?

IgNAR antibody domain C3

Sharks have smaller antibodies than usual. IgNAR shows significant structural differences to other antibodies. It has five constant domains (CH) per chain instead of the usual three, several disulfide bonds in unusual positions, and the complementarity-determining region 3 (CDR3) forms an extended loop covering the site which binds to a light chain in other antibodies. These differences, in combination with the phylogenetic age of the cartilaginous fishes, have led to the hypothesis that IgNAR could be more closely related to a primordial antigen-binding protein than the mammalian immunoglobulins. Non-vertebrates do not have antibodies at all. (read more DOI: 10.1073/pnas.1321502111 and Wikipedia)

2w9p: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the potato multicystatin … such a surprising vegetable.

Potato Multicystatin

Potato (Solanum tuberosum) multicystatin an inhibitor of protease of the family Cys protease and found in the subphellogen layer of potato tubers. In contrast with cystatins from other plant and animal sources, this protein has a high molecular mass of 85 kDa/monomer, compared to 8 or 25 kDa. It can also bind and inhibit several Cys proteases (e.g., papain) simultaneously, and the term multicystatin thus refers to its multiple inhibitory domains (read more DOI: 10.1105/tpc.108.064717 and doi: 10.1105/tpc.108.064717)

2r73: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the Possum Milk Whey Lipocalin Trichosurin such a lovely animal, right?

https://www.rcsb.org/structure/2r73
  • PubMed Abstract: 

Lipocalins are extracellular proteins (17-25 kDa) that bind and transport small lipophilic molecules. Trichosurin, a protein from the milk whey of the common brushtail possum (read more DOI: 10.1042/BJ20070567 or PMC2049081/)

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Brushtail possum

4ox6: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the protein CcmK4 from Synechococcus elongatus … just a beautiful crystal!

CcmK4 from Synechococcus elongatus

CcmK4 is a protein forming the shell of protein-only bacterial organelles. these organelles are called microcompartments and are self-assembling (how amazing?) (read more DOI: 10.1021/sb500226j and Wikipedia)

Proteins at their best: crystals!

Getting bored on a Sunday night, I have decided to get lost into the world of protein crystals. Insulin is used as a crystal and they are even studied as functional materials nowadays.

To read more about them click HERE.

1uz2: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the Beta-Lactoglobulin that is a protein we find in our cappuccino or mozzarella. Pretty-looking, right?

ő≤-Lactoglobulin¬†is the major¬†whey protein¬†of¬†cow¬†and¬†sheep‘s¬†milk¬†(~3 g/l), and is also present in many other mammalian species; a notable exception being humans. no clear function has been identified for ő≤-lactoglobulin, this despite its being the biggest part of the fractional composition of the globular proteins isolated from whey¬†(read moreDOI:¬†10.1021/bi0362469 or Wikipedia)

1thw: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the THE SWEET PROTEIN THAUMATIN that is a protein much sweeter than common sugar but giving very little calories! Is the sweetener of the future coming from biotech?

This crystal structure belongs to the THE SWEET PROTEIN THAUMATIN
Thaumatin, the sweet protein.

Proteins can be sweet and thaumatin is one of the best int his respect. The thaumatins were first found as a mixture of proteins isolated from the katemfe fruit (Thaumatococcus daniellii Bennett) (marantaceae) of west Africa. Some proteins in the thaumatin family of sweeteners are roughly 2000 times more potent than sugar. Although very sweet, thaumatin’s taste is markedly different from sugar’s. The sweetness of thaumatin builds very slowly. Perception lasts a long time, leaving a liquorice-like aftertaste at high usage levels. Thaumatin is highly water-soluble, stable to heating, and stable under acidic conditions. (read more DOI: 10.1107/S0907444994005512 or Wikipedia)

1ncx: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the Troponin C that is a protein looking like a double hammer and very important for our heart!

Troponin C

Troponin C is key for muscle contraction. for its action, it binds calcium ions and it is a component of thin filaments, along with actin and tropomyosin. (read more at Wikipedia, Sciencedirect and DOI: 10.1016/s1097-2765(01)00318-5)

Proteins at their best: crystals!

Getting bored on a Sunday night, I have decided to get lost into the world of protein crystals. Insulin is used as a crystal and they are even studied as functional materials nowadays.

To read more about them click HERE.

1jhn: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the Crystal Structure of the Lumenal Domain of Calnexin that is a protein with a very long appendage… like a ball on the leash!

Crystal Structure of the Lumenal Domain of Calnexin

It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. Calnexin is a chaperone, meaning that its job is to assist protein to reach their correct folding and ensure quality control. It specifically acts to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum (read more at Wikipedia and DOI: 10.1016/s1097-2765(01)00318-5)

1i56: Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the SOLUTION STRUCTURE OF CA2+-BOUND STATE OF CANINE MILK LYSOZYME that is clearly a compact ball-like protein.

SOLUTION STRUCTURE OF CA2+-BOUND STATE OF CANINE MILK LYSOZYME

Lysozyme is a small protein that attacks bacteria and breaks down one of their crucial structures, the membrane that holds them together. In particular, it cleaves the ő≤-1,4-glycosidic bond between¬†N-acetylmuramic acid and¬†N-acetylglucosamine of¬†peptidoglycan. Made of sugars and crosslinked peptides, peptidoglycan gives structure and confers structural integrity to to know more. It degrades (hydrolyses)¬†peptidoglycan, the building block of bacterial cell-wall. Being able to attack one of the components present in all bacteria, it is a powerful weapon not only in medicine but also for biotech applications. (read more at Medium)

1BGE : Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP. Have a look at the NEW items with this protein!

This crystal structure belongs to the CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF) that is clearly a super curly protein!

CANINE AND BOVINE GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF)

This protein is a member of the cytokine family and carries sugar modiciation (they are glycoproteins) that stimulate the differentiation and proliferation of blood cells. They are small proteins with a molecular mass of about 19 kDa and an amino acid sequence identity of about 80%.The structure is formed by alpha-helices that form an antiparallel 4-alpha-helical bundle with up-up-down-down connectivity. The human and canine proteins are really somilar in structure to each other. (ref.DOI: 10.1006/jmbi.1993.1617)

Creativity in the SHOP

In moments of boredom or concern, seeing how beautiful the structures of nature are can reassure and inspire! I went back to my favourite molecules and selected some protein structures to bring some dynamism and creativity in our SHOP.

The coming posts will introduce the proteins featured one by one, to get familiar and feel more cozy.

Wool is a protein

I eat you lovely protein,

I cuddle you in my lab,

I Freeze you for new adventures,

And finally you warm me up.

Curly and long, you keep me safe

Through the winter like a jacket,

My natural fur.

Never lost love

My protein had lost is fluo,

It doesn’t greet me with a spark

At the end of the dark fridge anymore.

We were friends

And she left me.

Her curls flat free on the water now,

Her awesomeness remains in my book.

Missing my cofactor

The metal has left me.

I navigate like an empty protein

And lacking its energy

And best buddy.

No activity in sight.

I eat my chocolate and store my iron,

Like a well educated smiling kid.

Sweet protein life

Some proteins survive boiling,

Some enzymes live happily ever after

The long drop freezing,

Some peptides bind like a child to a mum,

Tight.

I will be a curly lysozyme today,

Hard working and efficient,

Yet sweet to taste.

Thank me

I am a

Rigid and versatile molecule

Of thousands of units.

I vibrate in the liquid.

I catch and release,

Selectively.

I make your cells work

And progress.

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